Endocrine Abstracts

Background: Pituitary apoplexy occurs when a tumor undergoes acute hemorrhage, infarct, or both. This often leads to acute severe symptoms (clinical) but can also occur without them and diagnosed on CT/MRI, surgery, pathology (subclinical). To investigate clinical and subclinical apoplexy in nonfunctioning tumors (n=221) from our database.Design: Retrospective review of clinical presentation, tumor characteristics and outcome of 24 patients, 11 fe...

Introduction: The association of autoimmune diseases in the same individual is common. It is well documented that Graves’ disease (GD) is associated to various autoimmune diseases, including: pernicious anemia, vitiligo, type 1 diabetes, Addison’s disease, systemic sclerosis, myasthenia gravis, Sjogren’s syndrome, rheumatoid arthritis and systemic lupus erythematosus. In addition, primary biliary cirrhosis (PBC) may be associated with rheumatoid arthritis, Sjogr...

Pituitary carcinoma is rare (0.1–0.2% of pituitary tumors), with a poor prognosis. It usually presents as invasive and secretory (ACTH or prolactin) macroadenoma. The diagnosis is confirmed by the presence of metastases. The latency period between the diagnosis of adenoma and carcinoma is variable (9.5 years for corticotrophinoma). The treatment includes surgery, radiotherapy and chemotherapy.We report a 58-year-old male, complaining of visual distu...

Introduction: Von Hippel-Lindau disease (VHLD) is a rare autosomal-dominant syndrome, characterized by the development of multiple cysts and tumours, namely retinal and central nervous system hemangioblastomas, renal cell carcinoma (RCC), phaeochromocytoma, pancreatic endocrine tumours (PET) and endolymphatic sac tumours.Most germinal mutations are missense, related to a high risk for presenting phaechromocytoma (specially if Arg167Trp mutation im...

Introduction: Traumatic brain injury (TBI) is considered a rare cause of pituitary dysfunction. Recently, some retrospective studies demonstrated that TBI-mediated hypopituitarism is more frequent than previously known. However, its prevalence and natural history are still unclear.Objectives: To evaluate the prevalence of hypopituitarism 1 year after TBI and the association between the seriousness of the traumatism and the pituitary deficits.<p class...

Introduction: High-resolution US and US FNA are techniques of great relevance in the evaluation of thyroid nodules. They are being used much more often by endocrinologists all over the world. In our Endocrinology Department, we started them in 2006; since then they have been progressively amplified. We present our results of US FNA performed from January 2007 until December 2009.Patients and methods: Two thousand eight hundred and seventy-seven FNA were ...

Introduction: Scientific progress allowed an evolution on the therapeutic of diabetes mellitus. Continuous subcutaneous insulin infusion therapy (CSII) is one good example, but, beside patients motivation little is known about other psychological factors of success in this therapeutic and how they contribute to quality of life (QoL).Objectives: Determining some psychopathological predictors of CSII satisfaction and QoL improvement in patients on CSII the...

Obesity is growing fast worldwide. Although environmental factors play a major role, endocrine dysfunction may contribute to the weight gain. We report an invasive macroprolactinoma diagnosed in obesity setting. A 35-year-old male was referred to our endocrine outpatient department due to grade 2 obesity (IMC 38.4 Kg/m2). His weight was increasing since the beginning of his professional activity at the age of 20 due to a sedentary lifestyle. On physical examination he had an h...

IntroductionShort stature (SS) assessment includes the documentation of growth hormone (GH) secretion via GH stimulation tests.ObjectivesTo study retrospectively GH stimulation test results among Greek children with SS and investigate differences among GH deficient (GHD) children vs idiopathic short stature (ISS).MethodsData were collected retrospectively from 190...

IntroductionThe management of patients with adrenal incidentaloma (AI) and mild autonomous cortisol secretion (MACS) is debated. This randomized study aimed to evaluate the effects of adrenalectomy on arterial hypertension (AH), glucose and lipid metabolism.MethodsWe consecutively evaluated 626 AI patients (referred to 3 Italian Centers between 06/2016 and 02/2020). According to the inclusion criteria, we enr...